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Updated: May 16, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of
W Wei1, Y Jiao, A Postlethwaite
1Institute of Endemic Fluorosis Disease, Center for Endemic Disease Control, Center for Disease Control and Prevention, Harbin Medical University, Harbin, PRC.
Abstract:
Dual-specificity phosphatases (DUSPs) is an emerging subclass of the protein tyrosine phosphatase gene superfamily, a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Recently, a series of investigations of DUSPs defined their essential roles in cell proliferation, cancer and the immune response. This review will focus on DUSP2, its involvement in different diseases and its potential as a therapeutic target.
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