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Epidemiology of cocirculating human rotaviruses in Iran

Zabihollah Shoja1, Somayeh Jalilvand, Talat Mokhtari-Azad

  • 1School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. zshoja@razi.tums.ac.ir

The Pediatric Infectious Disease Journal
|November 30, 2012
PubMed

Insights

Rotavirus gastroenteritis is a significant threat to children under five globally. In Iran, hospitalized children showed higher rotavirus rates, with G1P[8] being the most common genotype.

Area of Science:

  • Virology
  • Pediatrics
  • Public Health

Background:

  • Rotaviruses are a leading cause of severe diarrhea in young children worldwide.
  • Understanding rotavirus epidemiology is crucial for public health interventions.

Purpose of the Study:

  • To determine the prevalence and common genotypes of rotavirus in hospitalized children with acute gastroenteritis in Iran.
  • To compare rotavirus positivity rates between hospitalized and outpatient settings.

Main Methods:

  • Retrospective analysis of patient data.
  • Diagnostic testing for rotavirus in stool samples.
  • Genotyping of detected rotavirus strains.

Main Results:

  • Rotavirus positivity rates varied significantly, ranging from 15.3% to 67.6% in hospitalized children under five.
  • Hospitalized patients exhibited a significantly higher rotavirus detection rate compared to outpatients.
  • The G1P[8] genotype was the most frequently identified, with one study reporting a G4P[8] peak.

Conclusions:

  • Rotavirus remains a significant pathogen causing acute gastroenteritis in Iranian children requiring hospitalization.
  • Genotyping data, particularly the prevalence of G1P[8], can inform vaccine strategies and public health policies.

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