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The increased prevalence of left ventricular hypertrophy and concentric remodeling in U.K. Indian Asians compared

N S Chahal1, T K Lim, P Jain

  • 1Department of Cardiovascular Medicine, Northwick Park Hospital, Royal Brompton Hospital, Harrow, London, UK.

Journal of Human Hypertension
|November 30, 2012
PubMed

Insights

Indian Asian men in the UK have a significantly higher prevalence of left ventricular hypertrophy (LVH), a key cardiovascular disease (CVD) risk factor. This study highlights a critical gap in identifying CVD risk in this population.

Area of Science:

  • Cardiology
  • Population Health
  • Ethnic Health Disparities

Background:

  • UK Indian Asians experience disproportionately higher cardiovascular disease (CVD) mortality than European whites.
  • Validated tools to identify this elevated CVD risk are lacking.
  • Left ventricular hypertrophy (LVH) is a significant predictor of future CVD events, but its prevalence in Indian Asians is unknown.

Purpose of the Study:

  • To investigate the prevalence of LVH in healthy UK Indian Asians compared to European whites.
  • To assess the degree of concentric remodeling in these populations.
  • To inform the development of targeted CVD risk assessment tools.

Main Methods:

  • Transthoracic echocardiography was used to assess LVH and relative wall thickness.
  • 2127 healthy subjects aged 35-75 years were recruited for the LOLIPOP study.
  • Prevalence of LVH and concentric remodeling were compared between ethnic groups.

Main Results:

  • LVH prevalence was significantly higher in Indian Asian men versus European white men (adjusted OR 2.8).
  • Indian Asians exhibited a greater degree of concentric remodeling compared to European whites (adjusted RWT men: 0.41 vs 0.39; women: 0.40 vs 0.38).
  • An almost threefold higher prevalence of LVH was observed in Indian Asian men.

Conclusions:

  • Indian Asian men have a substantially higher prevalence of LVH, indicating increased CVD risk.
  • Greater concentric remodeling in both Indian Asian men and women suggests underlying pathophysiological differences.
  • Further research into the mechanisms of LV remodeling and blood pressure in Indian Asians is crucial to address excess CVD mortality.

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