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Published on: April 1, 2019
Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis
Zhijiao Zhang1, Hang Zhu, Xudi Pu
1School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China.
BMC Infectious Diseases
|November 30, 2012
Summary
This meta-analysis found no significant link between the Tumor Necrosis Factor alpha (-238G/A) gene polymorphism and tuberculosis susceptibility. The study included 2723 subjects, confirming no association across various subgroups.
Area of Science:
- Immunogenetics
- Infectious Disease Epidemiology
Background:
- Tumor Necrosis Factor alpha (TNF-α) is crucial for controlling tuberculosis (TB).
- The association between the TNF -238G/A polymorphism and TB susceptibility requires further clarification.
- A comprehensive meta-analysis was conducted to precisely estimate this relationship.
Purpose of the Study:
- To determine the association between the TNF -238G/A polymorphism and tuberculosis susceptibility.
- To provide a more accurate estimate by synthesizing data from multiple studies.
Main Methods:
- A systematic literature search was performed.
- A fixed-effect model was used to calculate pooled odds ratios (OR) with 95% confidence intervals (CI).
- Heterogeneity and publication bias were assessed using Q-test, I-squared statistic, Begg's funnel plot, and Egger's test.
Main Results:
- Nine case-control studies comprising 2723 subjects were included.
- No significant heterogeneity or publication bias was observed.
- The meta-analysis revealed no significant association between the TNF -238G/A polymorphism and TB susceptibility (GA+AA vs. GG: OR=1.005, 95% CI: 0.765-1.319; A vs. G: OR=1.000, 95% CI: 0.769-1.300).
- Subgroup analyses by ethnicity, TB type, and HIV status also showed no significant associations.
Conclusions:
- This meta-analysis of 2723 subjects found no evidence of an association between the TNF -238G/A polymorphism and tuberculosis susceptibility.
- The findings suggest that this specific TNF polymorphism may not be a significant genetic risk factor for tuberculosis.
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