A phantom approach to interscanner comparability of computed tomographic brain perfusion parameters
Related Experiment Video
Updated: May 16, 2026
Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
Published on: June 7, 2024
Christian Mathys1, Konrad Rybacki, Hans-Jörg Wittsack
1Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany. mathys@uni-duesseldorf.de
Objective:
This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.
Methods:
A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.
Results:
Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.
Conclusions:
In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.
More Related Videos
06:45Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
Published on: June 2, 2023
15:10A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013