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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Updated: May 16, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Telomeres and atherosclerosis.

S Khan1, A A Chuturgoon, D P Naidoo

  • 1Department of Cardiology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. khans19@ukzn.ac.za

Cardiovascular Journal of Africa
|November 30, 2012
PubMed
Summary
This summary is machine-generated.

Telomere length, a marker of biological aging, is linked to cardiovascular disease and cancer. Shortened telomeres may predict heart disease risk, and therapies targeting telomeres offer new treatment strategies for atherosclerosis.

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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

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Last Updated: May 16, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Area of Science:

  • Genetics
  • Cardiology
  • Gerontology

Background:

  • Atherosclerotic cardiovascular disease and cancer are leading causes of death in aging organisms.
  • Dysregulation of telomere homeostasis links these age-related disorders.
  • Telomeres, chromosome end structures, shorten with cell replication, indicating biological age.

Purpose of the Study:

  • To review evidence linking telomere biology to atherosclerosis.
  • To discuss methods for preserving telomere length.
  • To explore telomere length as a cardiovascular risk predictor.

Main Methods:

  • Review of experimental and clinical evidence.
  • Analysis of studies associating telomere length with coronary artery disease (CAD).
  • Examination of the link between CAD risk factors, type 2 diabetes, telomere shortening, and cellular senescence.

Main Results:

  • Shortened telomeres are associated with cellular senescence in endothelial cells of atherosclerotic plaques.
  • Studies consistently link shorter telomere length to coronary artery disease (CAD).
  • CAD risk factors, like type 2 diabetes, are connected to telomere shortening and senescence.

Conclusions:

  • Telomere length assessment may predict cardiovascular risk and mortality better than current markers.
  • Anti-senescence therapies targeting telomeres are a promising strategy for atherosclerosis treatment.
  • Understanding telomere biology is crucial for addressing premature aging syndromes like CAD and diabetes.