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The impact of hepatitis A virus infection on hepatitis C virus infection: a competitive exclusion hypothesis

Marcos Amaku1, Francisco Antonio Bezerra Coutinho, Eleazar Chaib

  • 1School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.

Bulletin of Mathematical Biology
|November 30, 2012
PubMed

We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.

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