Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Broad-Temperature Polymerase in Nucleic Acid Amplification-Based Diagnostics: From Thermal Precision to Dynamic Conditions.

ACS sensors·2026
Same author

Loss of Schwann cell's normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor.

Molecular & cellular oncology·2025
Same author

Measuring Oligovalent Peptide-Virus Interactions Using Electrically Controllable DNA Nanostructures.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Heat Treatment of Hazelnut Allergens Monitored by Polyclonal Sera and Epitope Fingerprinting.

Foods (Basel, Switzerland)·2024
Same author

Point-of-Care Diagnostics Using Self-heating Elements from Smart Food Packaging: Moving Towards Instrument-Free Nucleic Acid-Based Detection.

Molecular diagnosis & therapy·2024
Same author

Specific features of epitope-MIPs and whole-protein MIPs as illustrated for AFP and RBD of SARS-CoV-2.

Mikrochimica acta·2024

Related Experiment Video

Updated: May 16, 2026

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents
10:16

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Published on: August 16, 2024

Platform technologies for molecular diagnostics near the patient's bedside.

Soeren Schumacher1, Christine Lüdecke, Eva Ehrentreich-Förster

  • 1Fraunhofer Institute for Biomedical Engineering IBMT, Branch Potsdam, Am Mühlenberg 13, 14476, Potsdam, Germany, soeren.schumacher@ibmt.fraunhofer.de.

Advances in Biochemical Engineering/Biotechnology
|November 30, 2012
PubMed
Summary

Lab-on-Chip systems offer a solution for rising diagnostic needs, driven by molecular medicine and global population changes. This modular, credit-card-sized system integrates assay functionalities for cost-effective, reliable diagnostics.

More Related Videos

On-Site Molecular Detection of Soil-Borne Phytopathogens Using a Portable Real-Time PCR System
14:15

On-Site Molecular Detection of Soil-Borne Phytopathogens Using a Portable Real-Time PCR System

Published on: February 23, 2018

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Related Experiment Videos

Last Updated: May 16, 2026

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents
10:16

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

Published on: August 16, 2024

On-Site Molecular Detection of Soil-Borne Phytopathogens Using a Portable Real-Time PCR System
14:15

On-Site Molecular Detection of Soil-Borne Phytopathogens Using a Portable Real-Time PCR System

Published on: February 23, 2018

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Diagnostics Technology

Background:

  • Increasing demand for rapid, reliable diagnostics due to advancements in molecular medicine and global demographic shifts.
  • Need for cost-effective and accessible diagnostic solutions, particularly in developing and aging populations.
  • Limitations of traditional diagnostic methods in terms of speed, cost, and accessibility.

Purpose of the Study:

  • To describe a novel modular Lab-on-Chip system developed by a consortium of Fraunhofer institutes.
  • To outline generic design rules for Lab-on-Chip systems and their application in a modular platform.
  • To demonstrate the integration of biomedical assays and assess the production feasibility of the developed system.

Main Methods:

  • Development of a credit-card-sized cartridge with integrated pumping and heating functionalities, eliminating fluidic interfaces.
  • Modular design allowing for the integration of either optical or electrochemical sensors tailored to specific assays.
  • Establishment of generic design rules for Lab-on-Chip systems.

Main Results:

  • A self-contained, modular Lab-on-Chip system comprising a cartridge and base station was successfully developed.
  • The system's modularity enables customization for various biomedical assays through sensor integration.
  • The design facilitates cost-effective production, addressing the need for affordable diagnostics.

Conclusions:

  • The developed modular Lab-on-Chip system offers a promising solution for accessible and reliable diagnostics.
  • The system's design principles and production possibilities support its potential mainstream adoption.
  • This technology addresses the growing global need for advanced yet affordable medical testing.