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PTGDR polymorphisms and susceptibility to asthma: a meta-analysis
Young Ho Lee1, Sung Jae Choi, Jong Dae Ji
1Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, South Korea. lyhcgh@korea.ac.kr
Molecular Biology Reports
|November 30, 2012
Summary
The prostaglandin D2 receptor (PTGDR) -549 C/T polymorphism increases asthma susceptibility in European adults. Other PTGDR polymorphisms and haplotypes showed no significant association with asthma risk.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Asthma is a complex respiratory disease with a significant genetic component.
- The prostaglandin D2 receptor (PTGDR) plays a role in inflammatory pathways relevant to asthma.
- Investigating specific PTGDR gene polymorphisms may reveal genetic risk factors for asthma.
Purpose of the Study:
- To determine if specific polymorphisms and haplotypes of the PTGDR gene are associated with asthma susceptibility.
- To analyze the PTGDR -549 C/T, -441 C/T, and -197 C/T polymorphisms and their haplotypes in relation to asthma.
- To conduct ethnicity- and age-stratified analyses to identify specific population groups at risk.
Main Methods:
- A comprehensive meta-analysis of 13 comparative studies involving 7,155 asthma patients and 7,285 controls.
- Analysis of PTGDR polymorphisms (-549 C/T, -441 C/T, -197 C/T) using allele contrast, recessive, dominant, and additive models.
- Haplotype analysis of PTGDR (CCC and TCT) and stratified meta-analyses by ethnicity and age.
Main Results:
- A significant association was found between the PTGDR -549 C/T polymorphism and asthma (OR = 1.133).
- The PTGDR -549 C allele was associated with increased asthma risk in Europeans (OR = 1.192) and adults (OR = 1.248), but not in children.
- No significant associations were observed for PTGDR -441 C/T, -197 C/T polymorphisms, or the CCC and TCT haplotypes with asthma susceptibility.
Conclusions:
- The PTGDR -549 C/T polymorphism is a genetic risk factor for asthma, particularly in European adults.
- The PTGDR -441 C/T, -197 C/T polymorphisms, and specific haplotypes do not appear to confer asthma susceptibility.
- Further research may elucidate the precise mechanisms linking PTGDR variation to asthma pathogenesis in specific populations.
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