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Updated: May 16, 2026

Animal Models of Depression - Chronic Despair Model (CDM)
Published on: September 23, 2021
Novel galanin receptor subtype specific ligand in depression like behavior
Indrek Saar1, Johan Runesson, Jaak Järv
1Institute of Technology, University of Tartu, Tartu, Estonia. indrek_saar@hotmail.com
Abstract:
Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.
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