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Bladder and urethral function in a mouse model of cavernous nerve injury
Seong Ho Lee1, Jeffrey J Lysiak, William D Steers
1Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
Neurourology and Urodynamics
|November 30, 2012
Summary
Cavernous nerve injury (CNI) in mice temporarily reduced bladder compliance, capacity, and leak point pressure, with functional recovery observed by day 6. These findings indicate that CNI-induced lower urinary tract changes are reversible.
Area of Science:
- Urology
- Neuroscience
- Physiology
Background:
- Cavernous nerve injury (CNI) can impact lower urinary tract function.
- Understanding the temporal effects of CNI on bladder and urethral function is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the effects of bilateral cavernous nerve injury (CNI) on bladder and urethral function over time in a mouse model.
- To assess the reversibility of functional changes following CNI.
Main Methods:
- Male C57BL/6 mice underwent either sham operation (SO) or bilateral CNI.
- Bladder and urethral function were evaluated using cystometry (CMG) and leak point pressure (LPP) recording at multiple time points post-surgery (Days 1-10).
Main Results:
- CNI led to significant, transient decreases in bladder compliance, capacity, and LPP at early time points (Days 1-4).
- Non-voiding contractions (NVC) were observed consistently in the CNI group.
- While SO also caused transient changes, CNI-induced alterations showed a gradual recovery from Day 6 onwards.
Conclusions:
- Cavernous nerve injury causes temporary but significant alterations in lower urinary tract function, including reduced bladder compliance, capacity, and LPP.
- These functional deficits demonstrate a reversible pattern, with recovery commencing around Day 6 post-injury.
- The study suggests that CNI affects bladder and urethral function, but these effects are not permanent.
