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Reduced exercise capacity in Greek children with mild to moderate obstructive sleep apnea syndrome
Labrini Damianidou1, Maria Eboriadou, Andreas Giannopoulos
12nd Pediatric Department, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
Insights
Children with obstructive sleep apnea syndrome (OSAS) exhibit reduced exercise capacity. This study found lower peak oxygen uptake and heart rate in pediatric OSAS patients compared to controls, even in mild cases.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Exercise Physiology
Background:
- Obstructive sleep apnea syndrome (OSAS) is increasingly diagnosed in children.
- Impaired exercise capacity is known in adult OSAS patients, but pediatric data is lacking.
Purpose of the Study:
- To assess cardiopulmonary exercise response in children with OSAS.
- To correlate exercise capacity with OSAS severity.
Main Methods:
- 27 children with habitual snoring (OSAS group) and 13 healthy controls underwent polysomnography.
- Cardiopulmonary exercise testing (CPET) was performed on a cycle ergometer for all participants.
- OSAS severity was categorized based on the apnea-hypopnea index (AHI).
Main Results:
- Children with OSAS showed significantly lower maximal oxygen uptake (VO2max) compared to controls.
- OSAS patients exhibited lower VO2max percentage, reduced peak heart rate, and higher peak systolic blood pressure.
- These differences were observed even in children with mild OSAS.
Conclusions:
- Pediatric OSAS is associated with reduced exercise capacity.
- Even mild OSAS negatively impacts cardiopulmonary response to exercise in children.
- Findings highlight the importance of addressing OSAS for improving physical fitness in children.
Introduction:
Obstructive sleep apnea syndrome (OSAS) is a common disease that is increasingly recognized among pediatric population. The exercise capacity of adults with OSAS has been demonstrated to be impaired, but there are no data about pediatric exercise response.
Aim:
The aim of this study was to evaluate cardiopulmonary response to exercise in children with OSAS and to correlate exercise capacity and severity of OSAS.
Methods:
Twenty-seven children with habitual snoring (Group A) (mean age 10.5 ± 1.8 years) referred for overnight polysomnography and 13 apparently healthy controls (mean age 11 ± 1.5 years) were recruited. According to the apnea hypopnea index (AHI) group A consisted of 15 (55.6%) children with mild OSAS and 12 (44.4%) with moderate-severe OSAS. All children completed a maximal ramping cardiopulmonary exercise test (CPET) on cycle ergometer.
Results:
According to CPET children with OSAS had significantly lower VO2max (40.3 ± 8.4 ml/kg/min vs. 47.6 ± 7.9 ml/kg/min, P = 0.013) significantly lower VO2max (%) (77.7 ± 15 vs. 92.9 ± 10.5, P = 0.002), lower maximum heart-rate at peak exercise (86.6 ± 8.8 beat/min vs. 90.6 ± 7.2 beat/min) and higher systolic blood pressure level at peak exercise (145 ± 27.4 mmHg vs. 143.92 ± 20 mmHg) compared to control group.
Conclusion:
The present study demonstrates that young patients with OSAS, even with mild OSAS, had reduced exercise capacity as compared to control group.
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