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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: May 16, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Remodeling a tissue: subtraction adds insight.

Jeffrey D Axelrod1

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. jaxelrod@stanford.edu

Science Signaling
|November 30, 2012
PubMed
Summary

Understanding how gene expression patterns guide body formation, known as morphogenesis, is crucial. Integrating diverse scientific fields is accelerating our knowledge of the physical forces driving these developmental processes.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Biophysics

Background:

  • Patterning of gene expression is well-understood.
  • Translating gene expression patterns into physical forms (morphogenesis) remains a challenge.
  • Understanding the mechanics of morphogenesis is key to developmental biology.

Purpose of the Study:

  • To explore how patterned gene expression drives morphogenesis.
  • To integrate diverse scientific approaches for a comprehensive understanding of shape formation.
  • To accelerate progress in understanding the forces shaping biological forms.

Main Methods:

  • Interdisciplinary research combining cell biology, developmental biology, imaging, engineering, and computational sciences.
  • Investigating the link between gene expression and physical processes in development.

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Multicolor Time-lapse Imaging of Transgenic Zebrafish: Visualizing Retinal Stem Cells Activated by Targeted Neuronal Cell Ablation

Published on: September 20, 2010

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  • Utilizing advanced imaging and computational modeling.

    • Main Results:

    • Progress in understanding morphogenesis is accelerating due to interdisciplinary efforts.
    • A more integrated understanding of the forces shaping biological forms is emerging.
    • The study highlights the synergy between different scientific disciplines.

    Conclusions:

    • Integrating diverse scientific fields is essential for advancing the study of morphogenesis.
    • Understanding the physical basis of morphogenesis is critical for developmental biology.
    • Future research will benefit from continued interdisciplinary collaboration.