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Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Material01:20

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Updated: May 16, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
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Published on: November 30, 2022

GenBank.

Dennis A Benson1, Mark Cavanaugh, Karen Clark

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|November 30, 2012
PubMed
Summary
This summary is machine-generated.

GenBank is a vital public nucleotide sequence database, updated daily and globally accessible. It integrates diverse biological data, facilitating sequence similarity searches and research worldwide.

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Creation and Maintenance of a Living Biobank - How We Do It

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • GenBank is a primary public repository for nucleotide sequences.
  • It archives data from individual labs and large-scale sequencing initiatives.
  • Global data synchronization ensures comprehensive coverage.

Purpose of the Study:

  • To describe the GenBank database and its functionalities.
  • To highlight its role in scientific research and data accessibility.
  • To provide access points for retrieval and analysis.

Main Methods:

  • Data submission via BankIt and Sequin programs.
  • Daily data exchange with ENA and DDBJ.
  • Access through NCBI Entrez retrieval system and BLAST searches.

Main Results:

  • GenBank contains sequences from nearly 260,000 species.
  • Integration with other NCBI resources provides comprehensive data access.
  • Sequence similarity searches are enabled via BLAST.

Conclusions:

  • GenBank is an essential, globally integrated resource for nucleotide sequences.
  • It supports diverse research through data sharing and analysis tools.
  • Accessible via NCBI, it facilitates discovery in molecular biology and genomics.