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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

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Related Experiment Videos

[Pyoderma gangrenosum: case report].

Vlatka Cavka1, Mirna Situm, Sanja Poduje

  • 1Sestre milosrdnice University Hospital Center, University Department of Dermatovenereology, Zagreb, Croatia. vlatka.cavka@yahoo.com

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum, a rare skin condition, was successfully treated in a patient who also had Crohn's disease. Effective management involved corticosteroids and specialized wound care, leading to complete healing.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with systemic conditions.
  • Early diagnosis and management are crucial for patient outcomes.

Observation:

  • A 56-year-old patient presented with necrotic leg ulcerations and deteriorating physical status.
  • Clinical suspicion of PG was confirmed histologically.

Findings:

  • Extensive workup revealed Crohn's disease, characterized by colonic ulcerations and stenosis.
  • Histological examination confirmed both PG and Crohn's disease.

Implications:

  • This case highlights the importance of investigating systemic associations in PG.
  • Integrated treatment of corticosteroids and advanced wound care achieved complete ulcer epithelialization.
  • Early diagnosis and multidisciplinary management are key for patients with co-existing PG and inflammatory bowel disease.