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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

Tissue Injury: Inflammation and Repair

Tissue Injury: Inflammation and Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Updated: May 16, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

[Wounds and dermatoses].

Suzana Ozanić Bulić¹, Lena Kotrulja, Ines Sjerobabski-Masnec

¹Sestre milosrdnice University Hospital Center, University Department of Dermatovenereology, Zagreb, Croatia.

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti

|December 1, 2012

Summary

Wounds are common in many skin diseases, including those from vascular, autoimmune, and malignant causes. Effective wound management requires a multidisciplinary approach to prevent complications like sepsis and improve patient quality of life.

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Area of Science:

Dermatology
Wound Care
Pathophysiology

Context:

Wounds, including erosions and ulcerations, are characteristic of numerous skin diseases.
Conditions such as chronic venous insufficiency, autoimmune disorders, infections, metabolic diseases, malignancies, and environmental factors can lead to wound formation.
Specific dermatological entities like lichen planus, lichen sclerosus, toxic epidermal necrolysis, Kaposi sarcoma, and genodermatoses (e.g., Hailey-Hailey, Darier's disease) present with prominent wound stages.

Purpose:

To highlight the diverse etiologies and clinical presentations of skin-related wounds.
To emphasize the critical need for specialized, multidisciplinary therapeutic strategies for wound management.
To underscore the potential for severe complications and the importance of vigilant patient follow-up.

Summary:

Wounds are a significant feature across a spectrum of dermatological conditions, varying in cause and appearance.
Management often necessitates intensive care and a team-based approach to address complications such as sepsis and malignant transformation.
Specific diseases like toxic epidermal necrolysis and oral lichen planus carry high mortality risks or precancerous potential, respectively.

Impact:

Recognizing wounds as a commonality in diverse skin diseases necessitates a unified approach to treatment and research.
Multidisciplinary care is crucial for managing complex wounds, improving patient outcomes, and preventing life-threatening complications.
Understanding the link between chronic inflammation, wound development, and malignant transformation is vital for patient prognosis and quality of life.