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Updated: May 16, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
[Wounds in vascular and metabolic diseases]
Nada Kecelj Leskovec1, Dubravko Huljev, Marijetka Matoh
1University Department of Dermatovenereology, Ljubljana University Hospital Center, Ljubljana, Slovenia. nada.keceli@mf.uni-Ii.si
Abstract:
There are many causes of leg ulcer development; however, vascular etiology is most commonly involved. Venous or lymphatic causes underlay 80% and arterial or arteriovenous causes 20%-25% of cases. Over years, the prevalence of arteriovenous ulcers has increased due to the increased prevalence of peripheral arterial disease. Concerning metabolic reasons, diabetes is the most common underlying disease leading to ulcer formation, whereas calciphylaxis is a very rare one. In addition to the general principles of local ulcer therapy, additional therapy treating the cause of ulcer is necessary. Therapy of leg ulcers is manly interdisciplinary and should include a dermatologist, surgeon, internal medicine specialist, radiologist, general practitioner.
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