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Updated: May 16, 2026
Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
Published on: June 9, 2023
Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and
Hsiangkuo Yuan1, Yang Liu, Andrew M Fales
1Fitzpatrick Institute of Photonics, Departments of Biomedical Engineering and Chemistry, Duke University, Durham, North Carolina 27708, United States.
Abstract:
Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. To produce strong SERS intensity while retaining the nonaggregated state and biocompatibility needed for bioapplications, we integrated near-infrared (NIR) responsive plasmonic gold nanostars with resonant dyes for resonant SERS (SERRS). The SERRS on nanostars was several orders of magnitude greater than signals from SERRS on nanospheres and nonresonant SERS on nanostars. For the first time, we demonstrated quantitative multiplex detection using four unique nanostar SERRS probes in both in vitro solutions and ex vivo tissue samples under NIR excitation. With further optimization, in vivo tracking of multiple SERRS probes is possible.
