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Updated: May 16, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Informed prostate cancer risk-adjusted testing: a new paradigm.
Phillip D Stricker1, Mark Frydenberg, Andrew Kneebone
1St Vincent's Prostate Cancer Centre, Sydney, New South Wales, Australia.
BJU International
|December 1, 2012
Summary
Prostate cancer screening causes confusion. A risk-adjusted testing program could reduce unnecessary testing and treatment, especially for the elderly or those with severe health conditions, improving outcomes.
Area of Science:
- Oncology
- Urology
- Medical Diagnostics
Background:
- Prostate cancer screening is a contentious topic, leading to significant confusion among patients and healthcare providers.
- Current screening practices, often relying on prostate-specific antigen (PSA) testing, lack universal consensus and can result in overdiagnosis and overtreatment.
Purpose of the Study:
- To propose a novel risk-adjusted prostate cancer testing program.
- To reduce the number of individuals undergoing unnecessary screening and subsequent treatment.
- To optimize screening protocols for specific patient populations, including the elderly and those with comorbidities.
Main Methods:
- Development of a risk-adjusted model for prostate cancer screening.
- Analysis of potential benefits and harms of the proposed risk-adjusted approach compared to current standard practices.
- Identification of patient subgroups who would benefit most from targeted screening versus those for whom screening offers no clear advantage.
Main Results:
- A risk-adjusted testing program is projected to decrease the number of patients requiring screening and treatment to prevent a single cancer death.
- This approach would effectively eliminate inappropriate prostate-specific antigen (PSA) testing in elderly individuals and those with severe comorbidities.
- Improved resource allocation and reduced patient burden associated with unnecessary diagnostic procedures and treatments.
Conclusions:
- A risk-adjusted prostate cancer screening strategy offers a more personalized and efficient approach to cancer detection.
- Implementing such a program can mitigate the harms of overdiagnosis and overtreatment, particularly in vulnerable patient groups.
- This model has the potential to enhance the overall benefit-risk ratio of prostate cancer screening, improving patient outcomes and healthcare system efficiency.
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