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Updated: May 16, 2026

DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
Switching photonic and electrochemical functions of a DNAzyme by DNA machines
Xiaoqing Liu1, Angelica Niazov-Elkan, Fuan Wang
1Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Abstract:
DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.
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