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Updated: May 16, 2026

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
Cytotoxicity and antimicrobial activity of plants from New Zealand's subantarctic islands
S D Lorimer1, G Barns, A C Evans
1Plant Extracts Research Unit, New Zealand Institute for Crop and Food Research Ltd., Department of Chemistry, University of Otago.
Abstract:
A total of 86 species of bryophytes, lichens and vascular plants were collected from New Zealand's subantarctic Campbell and Auckland Islands, including 18 subantarctic endemic species. Extracts of these species have been screened for antimicrobial activity and toxicity towards a P388 cell line. Of the main taxonomic groups collected, the proportion of extracts with some biological activity was highest for liverworts (25/29), intermediate for flowering plants (17/26) and lowest for mosses and horn worts (4/22). Extracts of six species showed repeatable, high biological activity warranting further investigation. The cytotoxicity of Ranunculus pinguis was due to the presence of ranunculin.
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