Related Experiment Video
Updated: May 16, 2026
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Term neonatal encephalopathy antecedent cerebral palsy: a retrospective population-based study
Paulina Kyriakopoulos1, Maryam Oskoui, Lynn Dagenais
1Division of Pediatric Neurology, Montreal Children's Hospital-McGill University Health Center, Montreal, Quebec, Canada.
Summary
Neonatal encephalopathy in term-born children with cerebral palsy is linked to spastic quadriplegia and severe motor impairment. Communication difficulties were also more common in this group.
Area of Science:
- Neurology
- Pediatrics
- Developmental Pediatrics
Background:
- Cerebral palsy (CP) is a common neurodevelopmental disorder.
- Neonatal encephalopathy (NE) is a significant risk factor for CP.
- Understanding the clinical profile of term-born CP with antecedent NE is crucial for targeted interventions.
Purpose of the Study:
- To compare clinical characteristics of term-born CP children with and without moderate to severe NE.
- To investigate the association between antecedent NE and CP subtype, motor function severity, and comorbidities.
Main Methods:
- Retrospective cohort study using the Quebec Cerebral Palsy Registry (1999-2002).
- Comparison of neurologic subtype, Gross Motor Function Classification System (GMFCS) levels, and comorbidities between children with and without antecedent NE.
- Statistical analysis included chi-square and student t-tests.
Main Results:
- Out of 132 term-born CP children, 44 (33%) had antecedent NE.
- Spastic quadriplegia subtype and GMFCS Level III-V (non-independent ambulation) were significantly associated with antecedent NE.
- No difference in the mean number of comorbidities, but severe communication difficulties were more frequent in the NE group.
Conclusions:
- Antecedent moderate to severe NE in term-born CP is associated with a distinct clinical profile.
- This profile includes increased neuromotor impairment, greater functional gross motor severity, and a higher likelihood of communication difficulties.
Related Concept Videos
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...