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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 16, 2026

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
12:18

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

Published on: April 23, 2015

Accessing and mining data from large-scale mouse phenotyping projects.

Hugh Morgan1, Michelle Simon, Ann-Marie Mallon

  • 1MRC Mammalian Genetics Unit, MRC Harwell, Oxfordshire, OX11 0RD, UK.

International Review of Neurobiology
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

The International Mouse Phenotyping Consortium (IMPC) aims to discover gene functions through comprehensive mouse phenotyping. This study details the informatics infrastructure needed to manage and share the vast datasets generated by this large-scale genetic research initiative.

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Last Updated: May 16, 2026

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
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Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
16:23

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

Area of Science:

  • Genetics
  • Bioinformatics
  • Genomics

Background:

  • The International Mouse Phenotyping Consortium (IMPC) aims to systematically determine the function of all protein-coding genes in the mouse genome.
  • Understanding gene function is crucial for deciphering complex biological systems and disease mechanisms.

Purpose of the Study:

  • To describe the informatics methodologies for capturing and disseminating diverse, complex datasets generated by broad-based mouse phenotyping.
  • To outline plans for scaling these informatics implementations to manage the data surge from the IMPC.

Main Methods:

  • Implementing current methodologies for data acquisition and dissemination.
  • Developing and scaling informatics infrastructure within the Knockout Mouse Phenotyping Project (KOMP2).

Main Results:

  • Established current data capture and dissemination protocols.
  • Outlined strategies for managing large-scale phenotyping data.

Conclusions:

  • An integrated informatics infrastructure is essential for the success of the IMPC.
  • Scalable data management is critical for realizing the full potential of comprehensive mouse phenotyping for biological discovery.