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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
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Bioinformatics resources for behavior studies in the laboratory mouse.

Carol J Bult1

  • 1The Jackson Laboratory, Bar Harbor, Maine, USA. carol.bult@jax.org

International Review of Neurobiology
|December 1, 2012
PubMed
Summary

Discover how the Mouse Phenome Database (MPD) and Mouse Genome Informatics (MGI) databases aid in genetic and genomic behavior studies using laboratory mice, providing essential phenotype and genome data.

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Area of Science:

  • Genetics
  • Genomics
  • Behavioral Science

Background:

  • Laboratory mice are crucial models for genetic and genomic research.
  • Behavioral studies require comprehensive data on mouse phenotypes and genetics.
  • Existing databases offer valuable but sometimes fragmented information.

Purpose of the Study:

  • To highlight two key database resources for mouse genetic and genomic behavior studies.
  • To introduce the Mouse Phenome Database (MPD) and Mouse Genome Informatics (MGI).
  • To explain how these databases facilitate research on mouse behavior.

Main Methods:

  • Utilizing the Mouse Phenome Database (MPD) for baseline phenotype data.
  • Leveraging the Mouse Genome Informatics (MGI) for genetics and genomics information.
  • Employing integrated data for visualization and statistical analysis of behavioral phenotypes.

Main Results:

  • MPD provides extensive phenotype data across mouse strains and reference populations.
  • MPD offers tools for phenotype data visualization and statistical analysis.
  • MGI offers comprehensive genetic and genomic information, including gene function, phenotype, disease associations, and expression data.

Conclusions:

  • MPD and MGI are essential, complementary resources for researchers studying mouse behavior.
  • These databases streamline the use of laboratory mice in genetic and genomic research.
  • Access to integrated data enhances the understanding of genotype-phenotype relationships in behavior.