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Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
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Antiepileptic Drugs: Calcium Channel Blockers01:17

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Calcium channel blocking activity: Screening methods for plant derived compounds.

H Vuorela1, P Vuorela, K Törnquist

  • 1Division of Pharmacognosy, Department of Pharmacy, University of Helsinki, Finland.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Natural compounds, particularly coumarins, show calcium channel blocking activity, impacting heart and circulation. Further research is needed to understand their pharmacology and clinical use.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry

Background:

  • Calcium channel blockers are crucial for cardiovascular health.
  • Natural products, especially coumarins, exhibit calcium antagonistic properties.

Purpose of the Study:

  • To review natural compounds with calcium channel blocking activity.
  • To highlight current screening methods and future research directions.

Main Methods:

  • In vitro assays using aorta or ileum strips.
  • In vitro screening using animal cell lines.

Main Results:

  • Numerous natural compounds, mainly coumarins, possess calcium antagonistic activity.
  • Established in vitro screening methods exist, with limited in vivo assays.

Conclusions:

  • Natural products offer a promising source of novel calcium channel blockers.
  • More in vivo research is essential to elucidate pharmacology and clinical potential.