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Antidiabetic activity of Phyllanthus sellowianus in streptozotocin-induced diabetic rats
O Hnatyszyn1, J Miño, S Gorzalczany
1Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET).
Abstract:
The aqueous extract (5% w/v) of the stem barks of Phyllanthus sellowianus Müller Arg. (Euphorbiaceae) was administered orally at the dose of 4 ml/100 g body weight (corresponding to 2 g of dry plant material/kg body weight) to normal and streptozotocin-induced diabetic rats. Blood glucose was estimated 3 weeks after daily administration of the extract and was compared to the pre-treatment level. The results show that the administration of the extract significantly lowered the blood glucose in the diabetic rats.
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