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Anti-allergic effects of aged garlic extract
E Kyo1, N Uda, M Kakimoto
1Pharmacology & Safety Assessment Laboratory, Institute for OTC Research, Japan.
Summary
Aged Garlic Extract (AGE) effectively inhibited histamine release and allergic skin reactions in vitro and in vivo. This suggests AGE may modulate immune cells involved in allergic responses.
Area of Science:
- Immunology
- Pharmacology
Background:
- Mast cells, basophils, and T lymphocytes are key players in allergic reactions.
- Allergic inflammation involves complex cascade reactions mediated by these immune cells.
Purpose of the Study:
- To investigate the immunomodulatory effects of Aged Garlic Extract (AGE).
- To determine AGE's impact on mast cell and T lymphocyte function in allergic responses.
Main Methods:
- In vitro histamine release assay using rat basophil cell line RBL-2H3.
- In vivo IgE-mediated skin reaction model in mice.
- In vivo late-phase allergic reaction model in mice.
Main Results:
- AGE dose-dependently inhibited antigen-specific histamine release in vitro (up to 90%).
- AGE administration reduced antigen-specific ear swelling in IgE-mediated skin reactions (25-45%) and late-phase reactions (45-55%).
Conclusions:
- Aged Garlic Extract demonstrates significant inhibitory effects on key cellular components of allergic reactions.
- AGE may directly or indirectly modulate mast cells, basophils, and T lymphocytes, offering potential therapeutic benefits for allergic inflammation.
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