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Renal impairment is associated with coronary heart disease in HIV-positive men

Lucy J Campbell1, Mitesh Desai, Aseel Hegazi

  • 1School of Medicine, King's College, London, UK.

HIV Clinical Trials
|December 1, 2012
PubMed

Insights

Impaired kidney function, indicated by an estimated glomerular filtration rate (eGFR) below 75 mL/min, increases the risk of coronary heart disease (CHD) events in HIV-positive individuals. Prioritizing traditional CHD risk factor management is crucial for these patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Infectious Diseases (HIV/AIDS)

Background:

  • Chronic kidney disease (CKD) is a known risk factor for coronary heart disease (CHD).
  • The relationship between renal impairment and CHD in HIV-positive individuals is not well understood.

Purpose of the Study:

  • To determine the incidence of CHD in a cohort of HIV-positive patients.
  • To investigate the association between reduced estimated glomerular filtration rate (eGFR) and new-onset CHD.

Main Methods:

  • A cohort of 7,828 HIV-positive patients was followed from 2004 to 2009.
  • CHD events were identified via electronic records and elevated troponin levels.
  • Multivariate Poisson regression was used to analyze factors associated with CHD in HIV-positive men.

Main Results:

  • CHD incidence was 1.2 per 1,000 person-years; 32 events occurred in 28 patients.
  • Older age and hepatitis C virus (HCV) status were significantly associated with CHD.
  • An eGFR <75 mL/min was linked to incident CHD, independent of age.

Conclusions:

  • The incidence of CHD in this HIV-positive cohort was low.
  • Impaired renal function identifies HIV-positive patients at higher risk for CHD.
  • Management of traditional CHD risk factors should be prioritized in these patients.
Abstract

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