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Updated: May 16, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Antiinflammatory activity of flavonoids
A Panthong1, D Kanjanapothi, P Tuntiwachwuttikul
1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
Abstract:
Fourteen flavonoids (flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. The structural features necessary for antiinflammatory activity appear to be the presence of methoxyl groups at C5 and C7 of ring A and the pyrano ring B of the flavonoid molecule. Negligible or low antiinflammatory activities were found in the chalcone derivatives. The difference in the efficacy of the flavonoids tested possibly depends on their pharmacokinetic properties.
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