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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Does garlic alter the lipid pattern in normal volunteers?
T Saradeth1, S Seidl, K L Resch
1Dept. Phys. Med., Medical School, Vienna.
Summary
Garlic supplementation significantly lowered total cholesterol in individuals with normal lipid levels. This study demonstrates garlic
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Phytochemistry
Background:
- Previous clinical trials indicate garlic's efficacy in reducing elevated blood cholesterol.
- Limited data exists on garlic's impact on normal lipid profiles.
Purpose of the Study:
- To investigate the effects of garlic supplementation on blood lipid patterns in healthy volunteers.
- To assess changes in total cholesterol, triglycerides, and blood pressure.
Main Methods:
- A randomized, double-blind, placebo-controlled trial was conducted.
- Sixty-eight healthy volunteers received 600 mg of dried garlic powder daily for 15 weeks.
- A two-week wash-out period preceded the intervention.
Main Results:
- A significant reduction in total cholesterol was observed after 10 weeks (223 to 214 mg/dL).
- Triglycerides showed a numerical decrease but did not reach statistical significance.
- Blood pressure and placebo groups remained unchanged.
Conclusions:
- Garlic supplementation can induce changes in blood lipid levels, even in individuals with initially normal values.
- This suggests a potential role for garlic in maintaining healthy lipid profiles.
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