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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

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Does garlic alter the lipid pattern in normal volunteers?

T Saradeth¹, S Seidl, K L Resch

¹Dept. Phys. Med., Medical School, Vienna.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

|December 1, 2012

Summary

Garlic supplementation significantly lowered total cholesterol in individuals with normal lipid levels. This study demonstrates garlic

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Area of Science:

Nutritional Science
Cardiovascular Health
Phytochemistry

Background:

Previous clinical trials indicate garlic's efficacy in reducing elevated blood cholesterol.
Limited data exists on garlic's impact on normal lipid profiles.

Purpose of the Study:

To investigate the effects of garlic supplementation on blood lipid patterns in healthy volunteers.
To assess changes in total cholesterol, triglycerides, and blood pressure.

Main Methods:

A randomized, double-blind, placebo-controlled trial was conducted.
Sixty-eight healthy volunteers received 600 mg of dried garlic powder daily for 15 weeks.
A two-week wash-out period preceded the intervention.

Main Results:

A significant reduction in total cholesterol was observed after 10 weeks (223 to 214 mg/dL).
Triglycerides showed a numerical decrease but did not reach statistical significance.
Blood pressure and placebo groups remained unchanged.

Conclusions:

Garlic supplementation can induce changes in blood lipid levels, even in individuals with initially normal values.
This suggests a potential role for garlic in maintaining healthy lipid profiles.