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Increased Intracranial Pressure l: Introduction01:14

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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

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Updated: May 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

[Mechanisms underlying migraine chronification].

Mamoru Shibata1

  • 1Department of Neurology, School of Medicine, Keio University.

Rinsho Shinkeigaku = Clinical Neurology
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Migraine chronification, affecting 3% annually, involves brain changes and descending pain system dysfunction. Peripheral factors, like TRPV1 stimulation, may contribute to this chronic migraine development.

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Area of Science:

  • Neuroscience
  • Neurology
  • Pain Research

Context:

  • Migraine chronification affects 3% of cases annually, with risk factors like obesity and affective disorders.
  • Functional MRI and voxel-based morphometry reveal brain dysfunction and gray matter alterations in chronic migraine.
  • The role of organic brain changes and peripheral factors in migraine chronification requires further investigation.

Purpose:

  • To explore the neurobiological mechanisms underlying migraine chronification.
  • To investigate the role of descending anti-nociceptive systems and brain morphology in chronic migraine.
  • To examine the potential involvement of peripheral factors, such as TRPV1 stimulation, in migraine chronification.

Summary:

  • Chronification of migraine involves dysfunction in descending anti-nociceptive systems and morphological brain changes.
  • Studies suggest cortical spreading depression and TRPV1 stimulation in trigeminal nociceptors may play a role.
  • Botulinum neurotoxin type-A's efficacy in chronic migraine suggests peripheral factors are implicated.

Impact:

  • Provides insights into the complex mechanisms of migraine chronification.
  • Highlights potential therapeutic targets in the peripheral and central nervous systems.
  • Contributes to understanding the development of chronic migraine for improved patient outcomes.