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Related Experiment Video

Updated: May 16, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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[Whether or not ALS lesions spread contiguously?].

Tadashi Kanouchi1, Teruhiko Sekiguchi, Hidehiro Mizusawa

  • 1Clinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|December 1, 2012
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) lesion spread is not always contiguous. Some patients exhibit noncontiguous symptom progression, suggesting distinct mechanisms for local and regional ALS lesion development.

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Context:

  • Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neurodegenerative disease.
  • The prion-like propagation hypothesis suggests contiguous, domino-like spread of sALS lesions.
  • Understanding lesion spread mechanisms is crucial for developing targeted therapies.

Purpose:

  • To investigate the spatial progression patterns of lesions in sporadic amyotrophic lateral sclerosis (sALS).
  • To determine if sALS lesions spread contiguously or noncontiguously from the onset site.
  • To differentiate mechanisms underlying local progression versus regional spread of sALS.

Summary:

  • Clinical data from 53 sALS patients revealed noncontiguous symptom spread (e.g., bulbar to lower limbs, skipping upper limbs) in 18.9% of cases.
  • Analysis of 18 sALS patients with upper limb onset showed no significant correlation between local symptom progression speed and the interval to second region involvement.
  • Findings suggest distinct mechanisms govern local motor neuron degeneration and wider regional spread in sALS.

Impact:

  • Challenges the simple domino-like, prion-like spread model for all sALS cases.
  • Highlights the potential for noncontiguous pathological processes in sALS.
  • Provides evidence for divergent mechanisms in the progression of amyotrophic lateral sclerosis, guiding future research directions.