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Updated: May 16, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Osteosarcoma of the prostate after radiotherapy]
A Stangelberger1, C R Riedl, M Susani
1Abteilung für Urologie, Landesklinikum Baden, Baden, Österreich. anton.stangelberger@baden.lknoe.at
Aktuelle Urologie
|December 1, 2012
Summary
Prostate osteosarcoma is a rare cancer occurring after radiation therapy for prostate cancer. This aggressive tumor has a poor prognosis, even with treatment.
Area of Science:
- Oncology
- Uropathology
Background:
- Prostate cancer is a common malignancy in older men.
- Radiotherapy and androgen deprivation therapy are standard treatments for prostate cancer.
- Secondary malignancies can arise after cancer treatment.
Observation:
- A 74-year-old man with a history of prostate cancer treated with radiotherapy and androgen deprivation therapy presented with urinary retention.
- Transurethral resection of the prostate revealed poorly differentiated osteosarcoma.
- The patient had significant comorbidities, precluding chemotherapy.
Findings:
- Osteosarcoma of the prostate is a rare secondary malignancy.
- The patient's prostate osteosarcoma was poorly differentiated and metastatic at diagnosis.
- The patient had a short life expectancy following diagnosis.
Implications:
- This case highlights the risk of secondary osteosarcoma following prostate cancer radiotherapy.
- Early detection and management strategies for post-radiation sarcomas are crucial.
- Prostate osteosarcoma carries a poor prognosis, emphasizing the need for further research into effective treatments.
