[Modern imaging techniques in patients with multiple myeloma]

Area of Science:

• Radiology and Nuclear Medicine
• Oncology
• Hematology

Context:

• Multiple myeloma diagnosis and staging rely heavily on imaging.
• Differentiating multiple myeloma from other plasma cell disorders requires accurate imaging.
• Conventional radiography, while accessible, has limitations in sensitivity and specificity.

Purpose:

• To evaluate the role of various imaging modalities in multiple myeloma.
• To compare the diagnostic capabilities of conventional radiography, low-dose CT, MRI, and PET/CT.
• To provide guidance on optimal imaging strategies for myeloma detection and staging.

Summary:

• Conventional radiography remains a cost-effective standard for myeloma staging despite limitations.
• Whole-body low-dose CT offers improved detection of osseous and extraosseous lesions.
• Whole-body MRI and 18F-FDG PET/CT demonstrate the highest sensitivity for detecting bone marrow and extraosseous disease.

Impact:

• Advanced imaging techniques like whole-body MRI and PET/CT are crucial for comprehensive myeloma assessment.
• Optimized protocols and expert interpretation are essential for accurate diagnosis.
• These findings can guide the selection of appropriate imaging modalities for improved patient management.