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Published on: September 12, 2019
The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis
Verónica Rocío Vásquez-Garzón1, José Roberto Macias-Pérez, Mónica Noemí Jiménez-García
1Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del IPN, México D.F., México.
Abstract:
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
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