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Updated: May 16, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
Fulvia Gloria-Bottini1, Maria Banci, Patrizia Saccucci
1Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it
Background:
Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD.
Material/Methods:
The study included 381 patients admitted to the hospital for cardiovascular disease (232 patients with CAD and 149 with other cardiovascular problems) and 97 healthy newborns.
Results:
The proportion of subjects carrying the *Pro allele of p53 codon 72 and the high activity *B*C genotype of ACPACP₁ is higher in CAD (10.3%) than in non-CAD patients (2.0%) and in healthy newborns (6.2%).
Conclusions:
The data suggest an interaction between p53 codon 72 and ACPACP₁ wherein a positive effect of the p53 *Pro allele on susceptibility to CAD occurs, but only in the presence of the ACPACP₁ genotype characterized by high enzymatic activity.
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