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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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Related Experiment Video

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Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline
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Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline

Published on: January 5, 2017

EcoGene 3.0.

Jindan Zhou1, Kenneth E Rudd

  • 1Department of Biochemistry and Molecular Biology, The Miller School of Medicine, University of Miami, Miami, FL 33143, USA.

Nucleic Acids Research
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

EcoGene enhances the annotation of the Escherichia coli K-12 genome, a key model organism. This comprehensive database provides advanced tools and daily literature updates for improved genomic research.

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Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Escherichia coli K-12 is a well-established model organism in biological research.
  • Accurate and comprehensive genome annotation is crucial for understanding bacterial function.
  • Continuous updates and improvements to genomic databases are essential for scientific progress.

Purpose of the Study:

  • To detail the significant advancements and features of the EcoGene database and website.
  • To highlight EcoGene's role in improving the structural and functional annotation of the Escherichia coli K-12 MG1655(Seq) genome.
  • To showcase the integration of new tools and data sources for enhanced usability and research support.

Main Methods:

  • Development of graphic genome map features and Boolean query/Venn diagram capabilities.
  • Implementation of a genome-wide primer design tool (PrimerPairs) and customized sequence search (EcoBLAST).
  • Integration of proteome-wide Gene Ontology (GO) terms, a relational MySQL database, and web content management systems.

Main Results:

  • EcoGene now offers enhanced visualization, advanced data querying, and primer design tools.
  • The database provides access to over 2000 bacterial genomes and daily literature updates, linking abstracts to genes and topics.
  • Annotation updates are synchronized with NCBI GenBank, and experimental verifications ensure data accuracy.

Conclusions:

  • EcoGene serves as a continuously improving resource for Escherichia coli K-12 research.
  • The database's advanced features and comprehensive data facilitate deeper insights into bacterial genomics.
  • EcoGene's ongoing development supports the broader scientific community through accurate and accessible genomic information.