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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 16, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
04:55

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

Concise review: limbal stem cell deficiency, dysfunction, and distress.

Sajjad Ahmad1

  • 1St. Paul's Eye Unit, Royal Liverpool University Hospital, United Kingdom. s2ahm@doctors.org.uk

Stem Cells Translational Medicine
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Limbal stem cell deficiency is a painful eye condition where the cornea

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Last Updated: May 16, 2026

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Isolation and Identification of Limbal Niche Cells
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Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Tissue Engineering

Background:

  • The cornea's clarity is vital for vision, maintained by its epithelium.
  • The limbus, surrounding the cornea, harbors stem cells and acts as a barrier.
  • Dysfunction of the limbus leads to limbal stem cell deficiency, a blinding condition.

Purpose of the Study:

  • To discuss the current understanding of limbal stem cell deficiency pathophysiology.
  • To highlight the importance of identifying the cause of limbal stem cell deficiency for effective management.

Main Methods:

  • Review of existing literature on limbal stem cell deficiency.
  • Analysis of the roles of limbal stem cells and the limbal microenvironment.

Main Results:

  • Limbal stem cells are crucial for corneal epithelium maintenance.
  • The limbus prevents conjunctivalization of the cornea.
  • Causes of limbal stem cell deficiency include burns, inflammation, and genetic factors.

Conclusions:

  • Understanding whether limbal stem cells are lost, dysfunctional, or if the microenvironment is disturbed is key.
  • This knowledge is critical for developing targeted management strategies for limbal stem cell deficiency.