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Updated: May 16, 2026
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Concise review: cell therapy and tissue engineering for cardiovascular disease
Yuji Haraguchi1, Tatsuya Shimizu, Masayuki Yamato
1Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan.
Insights
Cell-based regenerative medicine offers a promising new therapy for cardiovascular diseases. Research is advancing, with clinical trials underway for tissue engineering approaches like scaffold-based and cell sheet-based therapies.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Tissue Engineering
Background:
- Cardiovascular disease (CVD) is a leading cause of death and illness globally.
- Current CVD therapies are actively researched and clinically applied.
- Cell-based regenerative medicine is emerging as a novel therapeutic strategy for CVD.
Purpose of the Study:
- To review recent advancements in cell sources for cardiovascular regenerative medicine.
- To summarize current cell-based regenerative therapies for cardiovascular diseases.
- To highlight tissue engineering approaches and ongoing clinical trials.
Main Methods:
- Literature review of recent research on cell sources and regenerative therapies for CVD.
- Focus on scaffold-based and cell sheet-based tissue engineering techniques.
- Analysis of data from ongoing clinical trials in the field.
Main Results:
- Identification of various cell sources suitable for cardiovascular regeneration.
- Demonstration of the potential of tissue engineering in CVD treatment.
- Confirmation of the initiation and progress of clinical trials.
Conclusions:
- Cell-based regenerative therapies hold significant promise for treating cardiovascular diseases.
- Tissue engineering strategies represent the next generation of these therapies.
- Continued research and clinical trials are crucial for realizing the full potential of regenerative medicine in cardiology.
Abstract:
Cardiovascular disease is a major cause of morbidity and mortality, especially in developed countries. Various therapies for cardiovascular disease are investigated actively and are performed clinically. Recently, cell-based regenerative medicine using several cell sources has appeared as an alternative therapy for curing cardiovascular diseases. Scaffold-based or cell sheet-based tissue engineering is focused as a new generational cell-based regenerative therapy, and the clinical trials have also been started. Cell-based regenerative therapies have an enormous potential for treating cardiovascular disease. This review summarizes the recent research of cell sources and cell-based-regenerative therapies for cardiovascular diseases.
