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Updated: May 16, 2026

09:24
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
Published on: October 3, 2014
Concise review: cell therapy and tissue engineering for cardiovascular disease
Yuji Haraguchi1, Tatsuya Shimizu, Masayuki Yamato
1Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan.
Stem Cells Translational Medicine
|December 1, 2012
Summary
Cell-based regenerative medicine offers a promising new therapy for cardiovascular diseases. Research is advancing, with clinical trials underway for tissue engineering approaches like scaffold-based and cell sheet-based therapies.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Tissue Engineering
Background:
- Cardiovascular disease (CVD) is a leading cause of death and illness globally.
- Current CVD therapies are actively researched and clinically applied.
- Cell-based regenerative medicine is emerging as a novel therapeutic strategy for CVD.
Purpose of the Study:
- To review recent advancements in cell sources for cardiovascular regenerative medicine.
- To summarize current cell-based regenerative therapies for cardiovascular diseases.
- To highlight tissue engineering approaches and ongoing clinical trials.
Main Methods:
- Literature review of recent research on cell sources and regenerative therapies for CVD.
- Focus on scaffold-based and cell sheet-based tissue engineering techniques.
- Analysis of data from ongoing clinical trials in the field.
Main Results:
- Identification of various cell sources suitable for cardiovascular regeneration.
- Demonstration of the potential of tissue engineering in CVD treatment.
- Confirmation of the initiation and progress of clinical trials.
Conclusions:
- Cell-based regenerative therapies hold significant promise for treating cardiovascular diseases.
- Tissue engineering strategies represent the next generation of these therapies.
- Continued research and clinical trials are crucial for realizing the full potential of regenerative medicine in cardiology.

