Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

6.4K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.4K
Methods of reducing fever01:22

Methods of reducing fever

1.6K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.6K
Types of Fever01:25

Types of Fever

1.7K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
1.7K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

3.9K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
3.9K
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

30
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
30
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

28
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
28

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High prevalence of soilborne and waterborne parasitic infections among schoolchildren, Belén District, Loreto Region, Peru.

Parasites, hosts and diseases·2026
Same author

Rapid Screening of Methicillin-Resistant <i>Staphylococcus aureus</i> Using MALDI-TOF MS and Machine Learning: A Randomized, Multicenter Study.

Analytical chemistry·2025
Same author

SARS-CoV-2 RNA-binding protein suppresses extracellular miRNA release.

RNA biology·2025
Same author

Genome diversity, population structure and MALDI-TOF MS profiling of Aspergillus oryzae/flavus strains from fermentation and wild environments.

BMC genomics·2025
Same author

The First Korean Case of <i>MAN1B1</i>-Congenital Disorder of Glycosylation Diagnosed Using Whole-Exome Sequencing and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry.

Annals of laboratory medicine·2024
Same author

Mature microRNA-binding protein QKI suppresses extracellular microRNA let-7b release.

Journal of cell science·2024
Same journal

From association to causation: interpreting propensity score-based analyses in real-world evidence.

Korean journal of anesthesiology·2026
Same journal

Video laryngeal mask-guided placement of electromyographic endotracheal tubes for intraoperative neuromonitoring during thyroidectomy: a simulator-based feasibility report.

Korean journal of anesthesiology·2026
Same journal

Amino acids for renal protection: time to implement in clinical practice.

Korean journal of anesthesiology·2026
Same journal

Easy DAO2 index: a novel hemodynamic risk factor for predicting mortality in surgical and critically ill patients.

Korean journal of anesthesiology·2026
Same journal

Association of dexmedetomidine with improved survival in ICU delirium.

Korean journal of anesthesiology·2026
Same journal

Cadaveric investigation of an ultrasound-guided obturator canal approach for obturator nerve block.

Korean journal of anesthesiology·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

11.1K

Malignant hyperthermia.

Dong-Chan Kim1

  • 1Department of Anesthesiology and Pain Medicine, Chonbuk National University Medical School, Jeonju, Korea.

Korean Journal of Anesthesiology
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Malignant hyperthermia (MH) is a rare, life-threatening muscle disorder triggered by anesthesia. Early detection and dantrolene treatment have significantly reduced MH mortality rates.

Keywords:
DiagnosisEpidemiologyMalignant hyperthermiaPathophysiologyTreatment

More Related Videos

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.8K
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.5K

Related Experiment Videos

Last Updated: May 5, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

11.1K
A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.8K
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

2.5K

Area of Science:

  • Pharmacogenetics
  • Skeletal Muscle Physiology
  • Anesthesiology

Background:

  • Malignant hyperthermia (MH) is a severe pharmacogenetic disorder affecting skeletal muscle.
  • It is triggered by anesthetics or stress, causing a hypermetabolic state due to uncontrolled calcium release.
  • Susceptibility (MHS) is inherited, often linked to RYR1 gene mutations affecting calcium regulation.

Purpose of the Study:

  • To review essential clinical knowledge of malignant hyperthermia (MH).
  • To highlight new developments in MH diagnosis and treatment.
  • To summarize the pathophysiology and genetic basis of MH susceptibility.

Main Methods:

  • Review of clinical literature on malignant hyperthermia (MH).
  • Analysis of diagnostic methods, including the muscle contracture test and genetic testing.
  • Examination of treatment strategies, focusing on dantrolene sodium and early detection.

Main Results:

  • Classic MH signs include hypercapnia, tachycardia, rigidity, hyperthermia, and acidosis.
  • The RYR1 gene harbors over 300 mutations linked to MH susceptibility.
  • Mortality has decreased from 70-80% to under 5% with modern management.

Conclusions:

  • Malignant hyperthermia (MH) management has advanced significantly.
  • Early detection via capnography and dantrolene treatment are crucial.
  • Genetic testing for MH susceptibility is becoming more prevalent.