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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
The case for launch of an international DNA-based birth cohort study
Igor Rudan1, Mickey Chopra, Yurii Aulchenko
1Centre for Population Health Sciences and Global Health Academy, University of Edinburgh, Scotland, UK ; Croatian Centre for Global Health, Faculty of Medicine, University of Split, Croatia.
Journal of Global Health
|December 1, 2012
Summary
Future global health initiatives must address social determinants and inequities in maternal and child health. An international birth cohort will leverage genomic research to tackle these persistent global health challenges.
Area of Science:
- Global Health
- Genomics
- Maternal and Child Health
Background:
- Global health agenda requires a shift beyond mortality reduction.
- Focus needed on social determinants, inequities, and sustainability of progress.
- Maternal and child health issues remain significant global disease burdens.
Purpose of the Study:
- To broaden the global health agenda beyond 2015.
- To utilize advanced research tools for understanding maternal and child health (MCH) problems.
- To establish an international birth cohort for MCH research in low- and middle-income countries (LMICs).
Main Methods:
- Employing high-throughput genetic and '-omics' research technologies.
- Designing conceptually new research studies.
- Developing stringent ethical frameworks for biological specimen and health data collection.
Main Results:
- Not applicable for this proposal-stage abstract.
- Not applicable for this proposal-stage abstract.
- Not applicable for this proposal-stage abstract.
Conclusions:
- An international birth cohort is proposed to address MCH challenges.
- Genomic research technologies will be applied to LMICs.
- This initiative aims to reduce the global burden of disease in MCH.
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