Primary Mediastinal Large B-Cell Lymphoma during Pregnancy

Area of Science:

• Oncology
• Hematology
• Obstetrics

Background:

• Non-Hodgkin's Lymphoma (NHL) is uncommon during pregnancy.
• Primary Mediastinal Large B-cell Lymphoma (PMLBCL) is a rare subtype of DLBCL, accounting for about 2.5% of NHL cases.
• This report details a rare instance of PMLBCL diagnosed in early pregnancy.

Purpose of the Study:

• To describe the management and outcomes of a pregnant patient diagnosed with PMLBCL.
• To evaluate the safety and efficacy of R-CHOP chemotherapy during pregnancy for PMLBCL.
• To highlight the feasibility of treating PMLBCL in pregnant patients.

Main Methods:

• Case report of a 22-year-old pregnant woman diagnosed with Stage IIA PMLBCL at 13 weeks gestation.
• Staging involved computed tomography (CT) and magnetic resonance imaging (MRI).
• Treatment administered was six cycles of R-CHOP chemotherapy during pregnancy, followed by (18)FDG-PET/CT scan post-delivery.

Main Results:

• The patient completed six cycles of R-CHOP during pregnancy.
• She delivered a healthy baby at 34 weeks gestation.
• Post-delivery imaging confirmed complete remission, with no evidence of disease at 20 months follow-up.
• The infant showed no developmental delays or physical abnormalities at 1 year of age.

Conclusions:

• Primary mediastinal large B-cell lymphoma can occur during pregnancy.
• R-CHOP chemotherapy is a viable and effective treatment option for PMLBCL in pregnant patients.
• Successful outcomes are achievable for both mother and child in this complex scenario.