Pseudomonas necrotizing fasciitis in an otherwise healthy infant

Shakeel Ahmed1, Syed Rehan Ali, Zahra Aziz Samani

  • 1Department of Paediatrics and Child Health, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Krachi 74800, Pakistan.

Insights

Necrotizing fasciitis, a severe soft tissue infection, is rarely caused by a single bacterium. This case report details a rare instance of monomicrobial necrotizing fasciitis in an infant due to Pseudomonas aeruginosa.

Area of Science:

  • Infectious Diseases
  • Pediatric Surgery
  • Microbiology

Background:

  • Necrotizing fasciitis is a rapidly progressive soft tissue infection with high mortality.
  • Monomicrobial necrotizing fasciitis is exceptionally rare, with few documented cases.
  • Pseudomonas aeruginosa is an opportunistic pathogen not commonly associated with this condition.

Purpose of the Study:

  • To report a rare case of monomicrobial necrotizing fasciitis caused by Pseudomonas aeruginosa in an infant.
  • To highlight the diagnostic and treatment challenges of this uncommon infection in a pediatric patient.

Main Methods:

  • Case report of a six-month-old female infant.
  • Clinical presentation, diagnosis, and treatment of necrotizing fasciitis.
  • Microbiological analysis of blood and tissue samples for Pseudomonas aeruginosa.

Main Results:

  • The infant presented with necrotizing fasciitis.
  • Pseudomonas aeruginosa was isolated from both blood and tissue samples.
  • The patient improved following intensive treatment.

Conclusions:

  • Monomicrobial necrotizing fasciitis due to Pseudomonas aeruginosa can occur in previously healthy infants.
  • Early diagnosis and aggressive treatment are crucial for favorable outcomes.
  • This case expands the understanding of rare etiologies of necrotizing fasciitis in pediatrics.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...