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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Published on: January 7, 2019

Daintain/AIF-1 (allograft inflammatory factor-1) promotes erythrocyte lysis and heme release probably via binding to

Yan-Ying Zhao1, Wei Wang, Dong-Jing Yan

  • 1College of Life Science and Technology, Southwest University for Nationalities, 610041, Chengdu, China.

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|December 4, 2012
PubMed

Free heme is potentially cytotoxic, particularly in the presence of oxidants or activated phagocytes. Daintain/AIF-1 (allograft inflammatory factor-1) is a macrophage factor that has been implicated in the regulation of inflammation. In the present study, daintain/AIF-1 was found to induce cytolysis of erythrocytes, resulting in heme release in vitro. Furthermore, the interacting protein of daintain/AIF-1 was purified by daintain/AIF-1-6 histidine antigen fusion protein nickel affinity chromatography. MALDI-TOF-MS analysis identified hemoglobin subunit beta-1 as an interacting protein of daintain/AIF-1.These data suggest that daintain/AIF-1 may be involved in heme-associated diseases.

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