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Updated: May 16, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
[The progress of studies on the relation between circadian rhythm disruption and cancer]
Shengwu Li1, Jia Wu, Xiaofeng Hu
1Acupuncture School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Abstract:
Like functions of other organisms, most of the physiological and behavioral functions of human are characterized by day-night rhythms. The rhythms which exhibit approximately 24-hour periodicity are called as circadian rhythms. This review is to summarize the progress of studies on relation of circadian rhythum disruption and cancer. The research results from animal experiments and population-based epidemiological studies have showed that cancer is closly related to circadian rhythm. Although numrous studies have demonstrated the close relation between circadian rhythm disruption and cancer, the mechanism is not yet clear. The current studies attributed decreased level of melatonin secretion and disruption of clock genes expression to the mechanism of carcinogenesis of circadian rhythm disruption.
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