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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
[Chronic inflammation and gastric cancer development].
Tsutomu Chiba1, Hiroyuki Marusawa, Yuko Matsumoto
1Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 4, 2012
Summary
Helicobacter pylori infection triggers ectopic expression of Activation-induced cytidine deaminase (AID) in gastric cells, promoting gene mutations and accelerating gastric cancer development via NF-kappaB signaling.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Biology
Background:
- Gastric cancer development involves gene aberrations.
- Activation-induced cytidine deaminase (AID) is crucial for immunoglobulin gene diversification.
- Helicobacter pylori (H. pylori) infection is linked to gastritis and gastric cancer.
Purpose of the Study:
- To investigate the role of ectopic AID expression in H. pylori-induced gastritis and gastric carcinogenesis.
- To elucidate the mechanism of AID induction by H. pylori in gastric mucosal cells.
Main Methods:
- Analysis of AID expression in H. pylori-positive human gastritis mucosa.
- In vitro experiments inducing H. pylori infection in gastric cells.
- Investigating the role of NF-kappaB signaling in AID induction.
- Assessing the impact of AID on p53 gene mutations using gene introduction and siRNA inhibition.
Main Results:
- Ectopic AID expression was observed in H. pylori-infected gastric mucosa.
- H. pylori infection induced AID, gene mutations, and deletions in gastric cells.
- NF-kappaB activation mediated H. pylori-induced AID expression.
- AID accelerated p53 mutations, and its inhibition reduced H. pylori-induced p53 mutations.
Conclusions:
- H. pylori infection induces ectopic AID expression in gastric mucosal cells through NF-kappaB activation.
- Ectopic AID contributes to gene mutations and aberrations, promoting gastric cancer development.
- Targeting AID may offer a therapeutic strategy for H. pylori-associated gastric cancer.
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