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Published on: November 10, 2017

An additional LDL-lowering effect of amlodipine; not only an antihypertensive?

Zekeriya Arslan1, Seyit Ahmet Ay, Murat Karaman

  • 1Department of Cardiology, Gelibolu Hospital , Canakkale , Turkey.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|December 4, 2012
PubMed

Insights

Valsartan and amlodipine were studied for their effects on lipid profiles in patients with essential hypertension. Amlodipine demonstrated a significant reduction in low-density lipoprotein (LDL) cholesterol compared to valsartan.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Hypertension is a key modifiable risk factor for cardiovascular diseases.
  • Hypertension is frequently associated with metabolic disorders, including dyslipidemia.
  • Elevated triglyceride and low-density lipoprotein (LDL) levels are significant contributors to cardiovascular disease development.

Purpose of the Study:

  • To investigate the impact of valsartan and amlodipine on lipid profiles in patients with newly diagnosed essential hypertension.
  • To compare the effects of valsartan versus amlodipine on lipid parameters in this patient group.

Main Methods:

  • A study was conducted on patients diagnosed with essential hypertension.
  • The effects of valsartan and amlodipine treatments on patient lipid profiles were analyzed.

Main Results:

  • Amlodipine showed a beneficial effect on the lipid profile.
  • Amlodipine significantly reduced low-density lipoprotein (LDL) cholesterol levels compared to valsartan.

Conclusions:

  • Amlodipine positively influences lipid profiles in hypertensive patients.
  • Considering plasma cholesterol levels may be important when selecting antihypertensive medications.

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