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Updated: May 16, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Abiraterone acetate for the treatment of prostate cancer

Charles J Ryan1, Michael L Cheng

  • 1Genitourinary Medical Oncology, UCSF Helen Diller Family Comprehensive Cancer Center, 1600 Divisadero Street, San Francisco, CA 94115, USA. ryanc@medicine.ucsf.edu

Expert Opinion on Pharmacotherapy
|December 4, 2012
PubMed
Abstract

Insights

Abiraterone acetate effectively treats castration-resistant prostate cancer (CRPC) by inhibiting androgen biosynthesis. This oral therapy is approved for patients post-docetaxel and shows promise before chemotherapy, targeting continued androgen receptor activation.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Prostate cancer is a leading cause of cancer death in men.
  • Androgen receptor (AR) signaling drives prostate cancer progression.
  • Castration-resistant prostate cancer (CRPC) persists despite low testosterone levels.

Purpose of the Study:

  • To review abiraterone acetate for CRPC management.
  • To summarize its rationale, mechanism, and clinical data.

Main Methods:

  • Review of existing literature on abiraterone acetate.
  • Analysis of clinical trial data for CRPC patients.

Main Results:

  • Abiraterone acetate is an oral, well-tolerated drug.
  • It targets continued AR activation in CRPC.
  • Approved for CRPC patients post-docetaxel.

Conclusions:

  • Abiraterone acetate represents a new paradigm in CRPC treatment.
  • It is effective in both pre- and post-chemotherapy settings.
  • Further research is needed for therapy optimization.

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