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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
Published on: July 16, 2012
Second generation direct antivirals and the way to interferon-free regimens in chronic HCV
Heather Lewis1, Morven Cunningham, Graham Foster
1Blizzard Institute of Cell and Molecular Science, Queen Mary University of London, 4 Newark Street, London, E1 2AD, United Kingdom. heatherilewis@hotmail.com
Abstract:
Treatment for those infected with chronic hepatitis C virus [HCV] has until recently been hampered by the lack of therapies other than pegylated interferon and ribavirin, which have limited efficacy and a difficult side effect profile. To address this, multiple new direct acting antiviral drugs which specifically target the non-structural proteins involved in HCV replication are in phase II/III development. This review will discuss the HCV replication cycle, mechanisms of action of the new direct acting antiviral drugs, results from published trials into their efficacy and the potential for interferon free treatment regimens in the future.
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